The foxa2 gene controls the birth and spontaneous degeneration of dopamine neurons in old age.
Parkinson disease affects more than 1% of the population over 60 y old. The dominant models for Parkinson disease are based on the use of chemical toxins to kill dopamine neurons, but do not address the risk factors that normally increase with age. Forkhead transcription factors are critical regulat...
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Public Library of Science (PLoS)
2007-12-01
|
| Series: | PLoS Biology |
| Online Access: | http://europepmc.org/articles/PMC2121110?pdf=render |