Chronic Hyperglycemia Drives Functional Impairment of Lymphocytes in Diabetic INSC94Y Transgenic Pigs

Chronic Hyperglycemia Drives Functional Impairment of Lymphocytes in Diabetic INSC94Y Transgenic Pigs

People with diabetes mellitus have an increased risk for infections, however, there is still a critical gap in precise knowledge about altered immune mechanisms in this disease. Since diabetic INSC94Y transgenic pigs exhibit elevated blood glucose and a stable diabetic phenotype soon after birth, th...

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Bibliographic Details
Main Authors: Isabella-Maria Giese, Marie-Christin Schilloks, Roxane L. Degroote, Maria Weigand, Simone Renner, Eckhard Wolf, Stefanie M. Hauck, Cornelia A. Deeg
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-01-01
Series:Frontiers in Immunology
Subjects:
animal model(s)
annexin A1
proliferation
diabetes mellitus
cell metabolism
PHA
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2020.607473/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2020.607473/full

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