Biological Effects on μ-Receptors Affinity and Selectivity of Arylpropenyl Chain Structural Modification on Diazatricyclodecane Derivatives

Biological Effects on μ-Receptors Affinity and Selectivity of Arylpropenyl Chain Structural Modification on Diazatricyclodecane Derivatives

Opioid analgesics are clinically used to relieve severe pain in acute postoperative and cancer pain, and also in the long term in chronic pain. The analgesic action is mediated by μ-, δ-, and κ-receptors, but currently, with few exceptions for k-agonists, μ-agonists are the only ones used in therapy...

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Bibliographic Details
Main Authors: Sandra Piras, Gabriele Murineddu, Giovanni Loriga, Antonio Carta, Enrica Battistello, Stefania Merighi, Stefania Gessi, Paola Corona, Battistina Asproni, Roberta Ibba, Veronika Temml, Daniela Schuster, Gérard Aimè Pinna
Format: Article
Language:English
Published: MDPI AG 2021-09-01
Series:Molecules
Subjects:
μ-receptors affinity
analgesic activity
9,10-diazatricyclo[4.2.1.1<sup>2,5</sup>]decane (DTD)
2,7-diazatricyclo[4.4.0.0<sup>3,8</sup>]decane
DTD derivatives
rigid benzo-condensed structure
Online Access:https://www.mdpi.com/1420-3049/26/18/5448

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https://www.mdpi.com/1420-3049/26/18/5448

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