Curcumol induces RIPK1/RIPK3 complex-dependent necroptosis via JNK1/2-ROS signaling in hepatic stellate cells

Curcumol induces RIPK1/RIPK3 complex-dependent necroptosis via JNK1/2-ROS signaling in hepatic stellate cells

It is generally recognized that hepatic fibrogenesis is an end result of increased extracellular matrix (ECM) production from the activation and proliferation of hepatic stellate cells (HSCs). An in-depth understanding of the mechanisms of HSC necroptosis might provide a new therapeutic strategy for...

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Bibliographic Details
Main Authors: Yan Jia, Feixia Wang, Qin Guo, Mengmeng Li, Ling Wang, Zili Zhang, Shuoyi Jiang, Huanhuan Jin, Anping Chen, Shanzhong Tan, Feng Zhang, Jiangjuan Shao, Shizhong Zheng
Format: Article
Language:English
Published: Elsevier 2018-10-01
Series:Redox Biology
Online Access:http://www.sciencedirect.com/science/article/pii/S2213231718305688

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http://www.sciencedirect.com/science/article/pii/S2213231718305688

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