Arachidonic Acid Metabolites of CYP450 Enzymes and HIF-1α Modulate Endothelium-Dependent Vasorelaxation in Sprague-Dawley Rats under Acute and Intermittent Hyperbaric Oxygenation

Arachidonic Acid Metabolites of CYP450 Enzymes and HIF-1α Modulate Endothelium-Dependent Vasorelaxation in Sprague-Dawley Rats under Acute and Intermittent Hyperbaric Oxygenation

Acetylcholine-induced vasorelaxation (AChIR) and responses to reduced pO<sub>2 </sub>(hypoxia-induced relaxation (HIR), 0% O<sub>2</sub>) were assessed in vitro in aortic rings of healthy male Sprague-Dawley rats (N = 252) under hyperbaric (HBO<sub>2</sub>) protoc...

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Bibliographic Details
Main Authors: Zrinka Mihaljević, Anita Matić, Ana Stupin, Ruža Frkanec, Branka Tavčar, Vanja Kelava, Ivana Tartaro Bujak, Nikolina Kolobarić, Aleksandar Kibel, Ines Drenjančević
Format: Article
Language:English
Published: MDPI AG 2020-09-01
Series:International Journal of Molecular Sciences
Subjects:
acetylcholine
aortic rings
epoxyeicosatrienoic acids
hyperbaric oxygenation
hypoxia
HIF-1α
Online Access:https://www.mdpi.com/1422-0067/21/17/6353

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https://www.mdpi.com/1422-0067/21/17/6353

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