Heparanase Promotes Tumor Growth and Liver Metastasis of Colorectal Cancer Cells by Activating the p38/MMP1 Axis

Heparanase Promotes Tumor Growth and Liver Metastasis of Colorectal Cancer Cells by Activating the p38/MMP1 Axis

Heparanase (HPSE), the only known mammalian endoglycosidase responsible for heparan sulfate cleavage, is a multi-faceted protein affecting multiple malignant behaviors in cancer cells. In this study, we examined the expression of HPSE in different colorectal cancer (CRC) cell lines. Gene manipulatio...

Full description

Bibliographic Details
Main Authors: Xue Liu, Zhi-hang Zhou, Wen Li, Shi-kun Zhang, Jing Li, Ming-Ju Zhou, Jin-Wen Song
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-04-01
Series:Frontiers in Oncology
Subjects:
colorectal cancer
heparanase
liver metastasis
MMP1
extracellular matrix
Online Access:https://www.frontiersin.org/article/10.3389/fonc.2019.00216/full

Internet

https://www.frontiersin.org/article/10.3389/fonc.2019.00216/full

Similar Items