In Silico Insights into Protein–Protein Interaction Disruptive Mutations in the PCSK9-LDLR Complex

In Silico Insights into Protein–Protein Interaction Disruptive Mutations in the PCSK9-LDLR Complex

Gain-of-function mutations in PCSK9 (proprotein convertase subtilisin/kexin type 9) lead to reduced uptake of LDL (low density lipoprotein) cholesterol and, therefore, increased plasma LDL levels. However, the mechanism by which these mutants reduce LDL reuptake is not fully understood. Here, we hav...

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Bibliographic Details
Main Authors: William R. Martin, Felice C. Lightstone, Feixiong Cheng
Format: Article
Language:English
Published: MDPI AG 2020-02-01
Series:International Journal of Molecular Sciences
Subjects:
pcsk9
ldlr
molecular dynamics
mm/pbsa
protein–protein interaction (ppi)
ppi disruptive mutation
residue interaction network
Online Access:https://www.mdpi.com/1422-0067/21/5/1550

Internet

https://www.mdpi.com/1422-0067/21/5/1550

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