Hypermethylation of CDKN2A exon 2 in tumor, tumor-adjacent and tumor-distant tissues from breast cancer patients

Hypermethylation of CDKN2A exon 2 in tumor, tumor-adjacent and tumor-distant tissues from breast cancer patients

Abstract Background Breast carcinogenesis is a multistep process involving genetic and epigenetic changes. Tumor tissues are frequently characterized by gene-specific hypermethylation and global DNA hypomethylation. Aberrant DNA methylation levels have, however, not only been found in tumors, but al...

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Bibliographic Details
Main Authors: Melanie Spitzwieser, Elisabeth Entfellner, Bettina Werner, Walter Pulverer, Georg Pfeiler, Stefan Hacker, Margit Cichna-Markl
Format: Article
Language:English
Published: BMC 2017-04-01
Series:BMC Cancer
Subjects:
DNA methylation
CDKN2A
Exon 2
Tumor suppressor genes
Breast cancer
Field cancerization
Online Access:http://link.springer.com/article/10.1186/s12885-017-3244-2

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http://link.springer.com/article/10.1186/s12885-017-3244-2

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