NMDA receptor GluN2A/GluN2B subunit ratio as synaptic trait of levodopa-induced dyskinesias: from experimental models to patients

NMDA receptor GluN2A/GluN2B subunit ratio as synaptic trait of levodopa-induced dyskinesias: from experimental models to patients

Levodopa-induced dyskinesias (LIDs) are major complications in the pharmacological management of Parkinson’s disease (PD). Abnormal glutamatergic transmission in the striatum is considered a key factor in the development of LIDs. This work aims at i. characterizing NMDA receptor GluN2A/GluN2B subuni...

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Bibliographic Details
Main Authors: Manuela eMellone, Jennifer eStanic, Ledia F Hernandez, Elena eIglesias, Elisa eZianni, Annalisa eLonghi, Annick ePrigent, Barbara ePicconi, Paolo eCalabresi, Etienne C Hirsch, Jose A Obeso, Monica eDi Luca, Fabrizio eGardoni
Format: Article
Language:English
Published: Frontiers Media S.A. 2015-07-01
Series:Frontiers in Cellular Neuroscience
Subjects:
Patients
Striatum
Parkinson’s disease
NMDA receptor
Levodopa-induced dyskinesias
6-OHDA rat model
Online Access:http://journal.frontiersin.org/Journal/10.3389/fncel.2015.00245/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fncel.2015.00245/full

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