Modelling of Immune Checkpoint Network Explains Synergistic Effects of Combined Immune Checkpoint Inhibitor Therapy and the Impact of Cytokines in Patient Response

Modelling of Immune Checkpoint Network Explains Synergistic Effects of Combined Immune Checkpoint Inhibitor Therapy and the Impact of Cytokines in Patient Response

After the success of the new generation of immune therapies, immune checkpoint receptors have become one important center of attention of molecular oncologists. The initial success and hopes of anti-programmed cell death protein 1 (anti-PD1) and anti-cytotoxic T-lymphocyte-associated protein 4 (anti...

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Bibliographic Details
Main Authors: Maria Kondratova, Emmanuel Barillot, Andrei Zinovyev, Laurence Calzone
Format: Article
Language:English
Published: MDPI AG 2020-12-01
Series:Cancers
Subjects:
tumour immunology
immune checkpoints
immunotherapy
signalling network
logic modelling
intercellular communication
Online Access:https://www.mdpi.com/2072-6694/12/12/3600

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https://www.mdpi.com/2072-6694/12/12/3600

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