Parkinson’s disease–associated VPS35 mutant reduces mitochondrial membrane potential and impairs PINK1/Parkin-mediated mitophagy

Parkinson’s disease–associated VPS35 mutant reduces mitochondrial membrane potential and impairs PINK1/Parkin-mediated mitophagy

Abstract Background Mitochondrial dysfunction plays a prominent role in the pathogenesis of Parkinson’s disease (PD), and several genes linked to familial PD, including PINK1 (encoding PTEN-induced putative kinase 1 [PINK1]) and PARK2 (encoding the E3 ubiquitin ligase Parkin), are directly involved...

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Bibliographic Details
Main Authors: Kai Yu Ma, Michiel R. Fokkens, Fulvio Reggiori, Muriel Mari, Dineke S. Verbeek
Format: Article
Language:English
Published: BMC 2021-06-01
Series:Translational Neurodegeneration
Subjects:
VPS35
PINK1
Parkin
Mitophagy
Mitochondrial membrane potential
Parkinson’s disease
Online Access:https://doi.org/10.1186/s40035-021-00243-4

Internet

https://doi.org/10.1186/s40035-021-00243-4

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