Usa1 protein facilitates substrate ubiquitylation through two separate domains.
BACKGROUND:Defects in protein folding are recognized as the root of many neurodegenerative disorders. In the endoplasmic reticulum (ER), secretory proteins are subjected to a stringent quality control process to eliminate misfolded proteins by the ER-associated degradation (ERAD) pathway. A novel ER...
Main Authors: | , , , |
---|---|
Format: | Article |
Language: | English |
Published: |
Public Library of Science (PLoS)
2009-10-01
|
Series: | PLoS ONE |
Online Access: | http://europepmc.org/articles/PMC2764048?pdf=render |