Overexpression of Bcl-2 attenuates MPP+, but not 6-ODHA, induced cell death in a dopaminergic neuronal cell line

Overexpression of Bcl-2 attenuates MPP+, but not 6-ODHA, induced cell death in a dopaminergic neuronal cell line

In order to investigate the role of Bcl-2 in dopaminergic cells, we established a dopaminergic neuronal cell line (MN9D) stably expressing human Bcl-2 (MN9D/Bcl-2) or neomycin (MN9D/Neo). Overexpression of Bcl-2 in MN9D cells attenuated cell death due to treatment of mitochondrial electron transport...

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Bibliographic Details
Main Authors: Young J. Oh, Shou C. Wong, Mark Moffat, Karen L. O'Malley
Format: Article
Language:English
Published: Elsevier 1995-06-01
Series:Neurobiology of Disease
Subjects:
Bcl-2
cell death
dopamine
MPP+
6-OHDA
reactive oxygen species
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996185700174

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http://www.sciencedirect.com/science/article/pii/S0969996185700174

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