Spatacsin and spastizin act in the same pathway required for proper spinal motor neuron axon outgrowth in zebrafish

Spatacsin and spastizin act in the same pathway required for proper spinal motor neuron axon outgrowth in zebrafish

Hereditary spastic paraplegias (HSPs) are rare neurological conditions caused by degeneration of the long axons of the cerebrospinal tracts, leading to locomotor impairment and additional neurological symptoms. There are more than 40 different causative genes, 24 of which have been identified, inclu...

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Bibliographic Details
Main Authors: Elodie Martin, Constantin Yanicostas, Agnès Rastetter, Seyedeh Maryam Alavi Naini, Alissia Maouedj, Edor Kabashi, Sophie Rivaud-Péchoux, Alexis Brice, Giovanni Stevanin, Nadia Soussi-Yanicostas
Format: Article
Language:English
Published: Elsevier 2012-12-01
Series:Neurobiology of Disease
Subjects:
Hereditary spastic paraplegia
SPG11
SPG15
Spatacsin
Spastizin
Zebrafish
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996112002446

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http://www.sciencedirect.com/science/article/pii/S0969996112002446

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