PC Deficiency Testing: Thrombin-Thrombomodulin as PC Activator and Aptamer-Based Enzyme Capturing Increase Diagnostic Accuracy

PC Deficiency Testing: Thrombin-Thrombomodulin as PC Activator and Aptamer-Based Enzyme Capturing Increase Diagnostic Accuracy

Protein C (PC) activity tests are routinely performed in a thrombophilia workup to screen for PC deficiency. Currently used tests combine conversion of PC to activated PC (APC) by the snake venom Protac with subsequent APC detection through hydrolysis of a chromogenic peptide substrate or prolongati...

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Bibliographic Details
Main Authors: Sara Reda, Heiko Rühl, Jana Witkowski, Jens Müller, Anna Pavlova, Johannes Oldenburg, Bernd Pötzsch
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-10-01
Series:Frontiers in Cardiovascular Medicine
Subjects:
functional protein C assays
thrombin-thrombomodulin complex
thrombophilia testing
aptamer
diagnostic sensitivity
Online Access:https://www.frontiersin.org/articles/10.3389/fcvm.2021.755281/full

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https://www.frontiersin.org/articles/10.3389/fcvm.2021.755281/full

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