Targeting of Histone Demethylases KDM5A and KDM6B Inhibits the Proliferation of Temozolomide-Resistant Glioblastoma Cells

Targeting of Histone Demethylases KDM5A and KDM6B Inhibits the Proliferation of Temozolomide-Resistant Glioblastoma Cells

Lysine histone demethylases (KDMs) are considered potential therapeutic targets in several tumors, including glioblastoma (GB). In particular, KDM5A is involved in the acquisition of temozolomide (TMZ) resistance in adult GB cells and UDX/KDM6B regulates H3K27 methylation, which is involved in the p...

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Bibliographic Details
Main Authors: Massimo Romani, Antonio Daga, Alessandra Forlani, Maria Pia Pistillo, Barbara Banelli
Format: Article
Language:English
Published: MDPI AG 2019-06-01
Series:Cancers
Subjects:
glioblastoma
epigenetics
histone methylation
KDM5A
KDM6B
JIB04
GSKJ4
temozolomide
drug resistance
Online Access:https://www.mdpi.com/2072-6694/11/6/878

Internet

https://www.mdpi.com/2072-6694/11/6/878

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