Differential Changes in Striatal Projection Neurons in R6/2 Transgenic Mice for Huntington's Disease

Differential Changes in Striatal Projection Neurons in R6/2 Transgenic Mice for Huntington's Disease

In early adult-onset Huntington's disease (HD), enkephalinergic striatopallidal projection neurons show preferential loss, reduced preproenkephalin (PPE) expression in surviving striatopallidal neurons, and loss of fibers in their projection target area. We examined PPE and PPT (preprotachykini...

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Bibliographic Details
Main Authors: Z. Sun, N. Del Mar, C. Meade, D. Goldowitz, A. Reiner
Format: Article
Language:English
Published: Elsevier 2002-12-01
Series:Neurobiology of Disease
Subjects:
Huntington's disease
basal ganglia
preproenkephalin
preprotachykinin
enkephalin
substance P
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996102905541

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http://www.sciencedirect.com/science/article/pii/S0969996102905541

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