Acute RhoA/Rho Kinase Inhibition Is Sufficient to Restore Phagocytic Capacity to Retinal Pigment Epithelium Lacking the Engulfment Receptor MerTK

Acute RhoA/Rho Kinase Inhibition Is Sufficient to Restore Phagocytic Capacity to Retinal Pigment Epithelium Lacking the Engulfment Receptor MerTK

The diurnal phagocytosis of spent photoreceptor outer segment fragments (POS) by retinal pigment epithelial (RPE) cells is essential for visual function. POS internalization by RPE cells requires the assembly of F-actin phagocytic cups beneath surface-tethered POS and Mer tyrosine kinase (MerTK) sig...

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Bibliographic Details
Main Authors: Yingyu Mao, Silvia C. Finnemann
Format: Article
Language:English
Published: MDPI AG 2021-07-01
Series:Cells
Subjects:
F-actin
MerTK
phagocytosis
TAM receptors
retinal pigment epithelium
RhoA
Online Access:https://www.mdpi.com/2073-4409/10/8/1927

Internet

https://www.mdpi.com/2073-4409/10/8/1927

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