Ion mobility-based sterolomics reveals spatially and temporally distinctive sterol lipids in the mouse brain

Sterol lipids are crucial for maintaining proper brain function. Here, the authors combine ion mobility-mass spectrometry and machine learning to assemble a sterol lipid library and characterize differences in sterol lipids across ten brain regions and two age groups in mice.

Bibliographic Details
Main Authors: Tongzhou Li, Yandong Yin, Zhiwei Zhou, Jiaqian Qiu, Wenbin Liu, Xueting Zhang, Kaiwen He, Yuping Cai, Zheng-Jiang Zhu
Format: Article
Language:English
Published: Nature Publishing Group 2021-07-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-021-24672-x