Glycochenodeoxycholate Promotes Liver Fibrosis in Mice with Hepatocellular Cholestasis

Glycochenodeoxycholate Promotes Liver Fibrosis in Mice with Hepatocellular Cholestasis

Hydrophobic bile salts are considered to promote liver fibrosis in cholestasis. However, evidence for this widely accepted hypothesis remains scarce. In established animal models of cholestasis, e.g., by <i>Mdr2</i> knockout, cholestasis and fibrosis are both secondary to biliary damage....

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Bibliographic Details
Main Authors: Simon Hohenester, Veronika Kanitz, Andreas E. Kremer, Coen C. Paulusma, Ralf Wimmer, Helen Kuehn, Gerald Denk, David Horst, Ronald Oude Elferink, Ulrich Beuers
Format: Article
Language:English
Published: MDPI AG 2020-01-01
Series:Cells
Subjects:
cholestasis
liver fibrosis
bile salts
hepatic stellate cell
egfr
Online Access:https://www.mdpi.com/2073-4409/9/2/281

Internet

https://www.mdpi.com/2073-4409/9/2/281

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