Increased 14-3-3 phosphorylation observed in Parkinson's disease reduces neuroprotective potential of 14-3-3 proteins

Increased 14-3-3 phosphorylation observed in Parkinson's disease reduces neuroprotective potential of 14-3-3 proteins

14-3-3 proteins are key regulators of cell survival. We have previously demonstrated that 14-3-3 levels are decreased in an alpha-synuclein (αsyn) mouse model of Parkinson's disease (PD), and that overexpression of certain 14-3-3 isoforms is protective in several PD models. Here we examine whet...

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Bibliographic Details
Main Authors: Sunny Rae Slone, Nicholas Lavalley, Michael McFerrin, Bing Wang, Talene Alene Yacoubian
Format: Article
Language:English
Published: Elsevier 2015-07-01
Series:Neurobiology of Disease
Subjects:
14-3-3 protein
Parkinson disease
Alpha-synuclein
Rotenone
Casein kinase
MPP+
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996115001084

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http://www.sciencedirect.com/science/article/pii/S0969996115001084

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