Single-cell RNA sequencing of peripheral blood mononuclear cells from acute Kawasaki disease patients

Single-cell RNA sequencing of peripheral blood mononuclear cells from acute Kawasaki disease patients

Immune cell changes are associated with Kawasaki disease (KD) pathogenesis. Here, using single cell RNA sequencing of PBMC, the authors show monocyte inflammatory genes are over-expressed in KD and TCR and BCR clonotype sequences show oligoclonal expansions after intravenous immunoglobulin therapy.

Bibliographic Details
Main Authors: Zhen Wang, Lijian Xie, Guohui Ding, Sirui Song, Liqin Chen, Guang Li, Min Xia, Dingding Han, Yue Zheng, Jia Liu, Tingting Xiao, Hong Zhang, Yujuan Huang, Yixue Li, Min Huang
Format: Article
Language:English
Published: Nature Publishing Group 2021-09-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-021-25771-5

Internet

https://doi.org/10.1038/s41467-021-25771-5

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