Targeting Carbonic Anhydrase IX Activity and Expression

Metastatic tumors are often hypoxic exhibiting a decrease in extracellular pH (~6.5) due to a metabolic transition described by the Warburg Effect. This shift in tumor cell metabolism alters the tumor milieu inducing tumor cell proliferation, angiogenesis, cell motility, invasiveness, and often res...

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Bibliographic Details
Main Authors: Brian P. Mahon, Melissa A. Pinard, Robert McKenna
Format: Article
Published: MDPI AG 2015-01-01
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