Trypanosoma brucei glycogen synthase kinase-3, a target for anti-trypanosomal drug development: a public-private partnership to identify novel leads.

Trypanosoma brucei glycogen synthase kinase-3, a target for anti-trypanosomal drug development: a public-private partnership to identify novel leads.

Trypanosoma brucei, the causative agent of Human African Trypanosomiasis (HAT), expresses two proteins with homology to human glycogen synthase kinase 3β (HsGSK-3) designated TbruGSK-3 short and TbruGSK-3 long. TbruGSK-3 short has previously been validated as a potential drug target and since this e...

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Bibliographic Details
Main Authors: Richard O Oduor, Kayode K Ojo, Gareth P Williams, Francois Bertelli, James Mills, Louis Maes, David C Pryde, Tanya Parkinson, Wesley C Van Voorhis, Tod P Holler
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2011-04-01
Series:PLoS Neglected Tropical Diseases
Online Access:http://europepmc.org/articles/PMC3071371?pdf=render

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http://europepmc.org/articles/PMC3071371?pdf=render

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