Perturbation of the Actin Cytoskeleton in Human Hepatoma Cells Influences Interleukin-6 (IL-6) Signaling, but Not Soluble IL-6 Receptor Generation or NF-κB Activation

Perturbation of the Actin Cytoskeleton in Human Hepatoma Cells Influences Interleukin-6 (IL-6) Signaling, but Not Soluble IL-6 Receptor Generation or NF-κB Activation

The transcription factor nuclear factor-kappa B (NF-κB) is critically involved in inflammation and cancer development. Activation of NF-κB induces the expression and release of several pro-inflammatory proteins, which include the cytokine interleukin-6 (IL-6). Perturbation of the actin cytoskeleton...

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Bibliographic Details
Main Authors: Elizabeta Georgieva, Stefan L. Leber, Cora Wex, Christoph Garbers
Format: Article
Language:English
Published: MDPI AG 2021-07-01
Series:International Journal of Molecular Sciences
Subjects:
interleukin-6
interleukin-6 receptor
NF-κB
actin
STAT3
Online Access:https://www.mdpi.com/1422-0067/22/13/7171

Internet

https://www.mdpi.com/1422-0067/22/13/7171

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