R292K Substitution and Drug Susceptibility of Influenza A(H7N9) Viruses

R292K Substitution and Drug Susceptibility of Influenza A(H7N9) Viruses

Neuraminidase inhibitors are the only licensed antiviral medications available to treat avian influenza A(H7N9) virus infections in humans. According to a neuraminidase inhibition assay, an R292K substitution reduced antiviral efficacy of inhibitors, especially oseltamivir, and decreased viral fitne...

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Bibliographic Details
Main Authors: Katrina Sleeman, Zhu Guo, John Barnes, Michael Shaw, James Stevens, Larisa V. Gubareva
Format: Article
Language:English
Published: Centers for Disease Control and Prevention 2013-09-01
Series:Emerging Infectious Diseases
Subjects:
H7N9
avian influenza
neuraminidase inhibitor
zanamivir
oseltamivir
R292K
Online Access:https://wwwnc.cdc.gov/eid/article/19/9/13-0724_article

Internet

https://wwwnc.cdc.gov/eid/article/19/9/13-0724_article

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