Solid-Phase Synthesis of New Trp(Nps)-Containing Dipeptide Derivatives as TRPV1 Channel Blockers

Solid-Phase Synthesis of New Trp(Nps)-Containing Dipeptide Derivatives as TRPV1 Channel Blockers

Trp(Nps)-Lys-NH2 derivatives, bearing alkyl or guanidine groups either at the N–terminus or on the Lys side-chain or at both positions were conveniently prepared on solid-phase and evaluated as TRPV1 channel antagonists.

Bibliographic Details
Main Authors: Rosario González-Muñiz, Antonio Ferrer-Montiel, Asia Fernández-Carvajal, Fernando Albericio, Laura Zaccaro, Miriam Royo, Mª Teresa García-López, Mª Jesús Pérez de Vega
Format: Article
Language:English
Published: MDPI AG 2010-07-01
Series:Molecules
Subjects:
solid-phase
Trp(Nps) dipeptides
TRPV1 channel blockers
Online Access:http://www.mdpi.com/1420-3049/15/7/4924/

Internet

http://www.mdpi.com/1420-3049/15/7/4924/

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