Obesity reduces bone density associated with activation of PPARγ and suppression of Wnt/β-catenin in rapidly growing male rats.

Obesity reduces bone density associated with activation of PPARγ and suppression of Wnt/β-catenin in rapidly growing male rats.

BACKGROUND: It is well established that excessive consumption of a high fat diet (HFD) results in obesity; however, the consequences of obesity on postnatal skeletal development have not been well studied. METHODOLOGY AND PRINCIPAL FINDINGS: Total enteral nutrition (TEN) was used to feed postnatal d...

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Bibliographic Details
Main Authors: Jin-Ran Chen, Oxana P Lazarenko, Xianli Wu, Yudong Tong, Michael L Blackburn, Kartik Shankar, Thomas M Badger, Martin J J Ronis
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2010-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC2965663?pdf=render

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http://europepmc.org/articles/PMC2965663?pdf=render

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