Sildenafil and bosentan plasma concentrations in a human immunodeficiency virus-infected patient with pulmonary arterial hypertension treated with ritonavir-boosted protease inhibitor

Sildenafil and bosentan plasma concentrations in a human immunodeficiency virus-infected patient with pulmonary arterial hypertension treated with ritonavir-boosted protease inhibitor

Sildenafil and bosentan are increasingly used for the treatment of pulmonary arterial hypertension (PAH) in HIV-infected patients. However, concerns exist about pharmacokinetic interactions among sildenafil, bosentan and antiretroviral drugs, including protease inhibitors (PI). We describe here the...

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Bibliographic Details
Main Authors: Pierangelo Chinello, Stefania Cicalini, Simona Pichini, Roberta Pacifici, Massimo Tempestilli, Maria P. Cicini, Leopoldo P. Pucillo, Nicola Petrosillo
Format: Article
Language:English
Published: MDPI AG 2015-03-01
Series:Infectious Disease Reports
Subjects:
human immunodeficiency virus, protease inhibitors, pulmonary arterial hypertension, sildenafil, bosentan
Online Access:http://www.pagepress.org/journals/index.php/idr/article/view/5822

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http://www.pagepress.org/journals/index.php/idr/article/view/5822

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