TREX1 Knockdown Induces an Interferon Response to HIV that Delays Viral Infection in Humanized Mice

TREX1 Knockdown Induces an Interferon Response to HIV that Delays Viral Infection in Humanized Mice

Despite their antiviral effect, the in vivo effect of interferons on HIV transmission is difficult to predict, because interferons also activate and recruit HIV-susceptible cells to sites of infection. HIV does not normally induce type I interferons in infected cells, but does if TREX1 is knocked do...

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Bibliographic Details
Main Authors: Lee Adam Wheeler, Radiana T. Trifonova, Vladimir Vrbanac, Natasha S. Barteneva, Xing Liu, Brooke Bollman, Lauren Onofrey, Sachin Mulik, Shahin Ranjbar, Andrew D. Luster, Andrew M. Tager, Judy Lieberman
Format: Article
Language:English
Published: Elsevier 2016-05-01
Series:Cell Reports
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124716304752

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http://www.sciencedirect.com/science/article/pii/S2211124716304752

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