Inhibition of Angiotensin Converting Enzyme Impairs Anti-staphylococcal Immune Function in a Preclinical Model of Implant Infection

Inhibition of Angiotensin Converting Enzyme Impairs Anti-staphylococcal Immune Function in a Preclinical Model of Implant Infection

Background: Evidence suggests the renin-angiotensin system (RAS) plays key immunomodulatory roles. In particular, angiotensin-converting enzyme (ACE) has been shown to play a role in antimicrobial host defense. ACE inhibitors (ACEi) and angiotensin receptor blockers (ARB) are some of the most common...

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Bibliographic Details
Main Authors: Rishi Trikha, Danielle Greig, Benjamin V. Kelley, Zeinab Mamouei, Troy Sekimura, Nicolas Cevallos, Thomas Olson, Ameen Chaudry, Clara Magyar, Daniel Leisman, Alexandra Stavrakis, Michael R. Yeaman, Nicholas M. Bernthal
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-09-01
Series:Frontiers in Immunology
Subjects:
implant
infection
angiotensin-converting enzyme inhibitor
angiotensin II receptor blocker
bioluminescence
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2020.01919/full

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https://www.frontiersin.org/article/10.3389/fimmu.2020.01919/full

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