Early VGLUT1-specific parallel fiber synaptic deficits and dysregulated cerebellar circuit in the KIKO mouse model of Friedreich ataxia

Early VGLUT1-specific parallel fiber synaptic deficits and dysregulated cerebellar circuit in the KIKO mouse model of Friedreich ataxia

Friedreich ataxia (FRDA) is an autosomal recessive neurodegenerative disorder with progressive ataxia that affects both the peripheral and central nervous system (CNS). While later CNS neuropathology involves loss of large principal neurons and glutamatergic and GABAergic synaptic terminals in the c...

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Bibliographic Details
Main Authors: Hong Lin, Jordi Magrane, Elisia M. Clark, Sarah M. Halawani, Nathan Warren, Amy Rattelle, David R. Lynch
Format: Article
Language:English
Published: The Company of Biologists 2017-12-01
Series:Disease Models & Mechanisms
Subjects:
VGLUT1
Parallel fiber synapse
Cerebellar circuit
KIKO
Friedreich ataxia
Online Access:http://dmm.biologists.org/content/10/12/1529

Internet

http://dmm.biologists.org/content/10/12/1529

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