Infectious Entry and Neutralization of Pathogenic JC Polyomaviruses

Infectious Entry and Neutralization of Pathogenic JC Polyomaviruses

Summary: Progressive multifocal leukoencephalopathy (PML) is a lethal brain disease caused by uncontrolled replication of JC polyomavirus (JCV). JCV strains recovered from the brains of PML patients carry mutations that prevent the engagement of sialylated glycans, which are thought to serve as rece...

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Main Authors: Eileen M. Geoghegan, Diana V. Pastrana, Rachel M. Schowalter, Upasana Ray, Wei Gao, Mitchell Ho, Gary T. Pauly, Dina M. Sigano, Campbell Kaynor, Ellen Cahir-McFarland, Benoit Combaluzier, Jan Grimm, Christopher B. Buck
Format: Article
Language:English
Published: Elsevier 2017-10-01
Series:Cell Reports
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124717314596

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http://www.sciencedirect.com/science/article/pii/S2211124717314596

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