Secondary donor-derived humanized CD19-modified CAR-T cells induce remission in relapsed/refractory mixed phenotype acute leukemia after allogeneic hematopoietic stem cell transplantation: a case report

Secondary donor-derived humanized CD19-modified CAR-T cells induce remission in relapsed/refractory mixed phenotype acute leukemia after allogeneic hematopoietic stem cell transplantation: a case report

Abstract Background Mixed phenotype acute leukemia (MPAL) is a rare leukemia and is regarded as a high-risk entity with a poor prognosis. Induction therapy of an acute lymphoblastic leukemia type or hybrid regimen and hematopoietic stem cell transplantation has been recommended for MPAL. However, th...

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Bibliographic Details
Main Authors: Meng-Yun Li, Zhi-Hong Lin, Ming-Ming Hu, Li-Qing Kang, Xiao-xia Wu, Qi-wei Chen, Xin Kong, Jian Zhang, Hui-Ying Qiu, De-Pei Wu
Format: Article
Language:English
Published: BMC 2020-08-01
Series:Biomarker Research
Subjects:
CD19
Chimeric antigen receptor T cells
Donor-derived
Humanized
Mixed phenotype acute leukemia
Online Access:http://link.springer.com/article/10.1186/s40364-020-00216-1

Internet

http://link.springer.com/article/10.1186/s40364-020-00216-1

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