Detection of up to 65% of Precancerous Lesions of the Human Colon and Rectum by Mutation Analysis of APC, K-Ras, B-Raf and CTNNB1

Detection of up to 65% of Precancerous Lesions of the Human Colon and Rectum by Mutation Analysis of APC, K-Ras, B-Raf and CTNNB1

In the present study a recently conceived 4-gene marker panel covering the Wnt and Ras-Raf-MEK-MAPK signaling pathways was used to analyze 20 colorectal serrated lesions and 41 colorectal adenoma samples and to determine the percentage of each of the above-mentioned potentially precancerous lesions...

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Bibliographic Details
Main Authors: Daniela Schatz, Kornelia Berghof-Jäger, Pablo Steinberg, Mandy Schneider, Bettina Scholtka, Uwe Gottschalk, Siegbert Faiss
Format: Article
Language:English
Published: MDPI AG 2010-12-01
Series:Cancers
Subjects:
adenomas
APC
B-Raf
CTNNB1
gene mutations
human colon
serrated lesions
K-Ras
primer panel
Online Access:http://www.mdpi.com/2072-6694/3/1/91/

Internet

http://www.mdpi.com/2072-6694/3/1/91/

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