Potential Use of Gluconate in Cancer Therapy

Potential Use of Gluconate in Cancer Therapy

We have recently discovered that cancer cells take up extracellular citrate through plasma membrane citrate transporter (pmCiC) and advantageously use citrate for their metabolism. Citrate uptake can be blocked with gluconate and this results in decreased tumor growth and altered metabolic character...

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Bibliographic Details
Main Authors: Maria E. Mycielska, Markus T. J. Mohr, Katharina Schmidt, Konstantin Drexler, Petra Rümmele, Sebastian Haferkamp, Hans J. Schlitt, Andreas Gaumann, Jerzy Adamski, Edward K. Geissler
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-06-01
Series:Frontiers in Oncology
Subjects:
gluconate
cancer metabolism
citrate
metabolic targeting
transporter
Online Access:https://www.frontiersin.org/article/10.3389/fonc.2019.00522/full

Internet

https://www.frontiersin.org/article/10.3389/fonc.2019.00522/full

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