In vivo cell biological screening identifies an endocytic capture mechanism for T-tubule formation

It is unclear how the T-tubule structure of skeletal muscle, which regulates coordinated muscle contraction, forms. Here, the authors develop a four-dimensional quantitative model for T-tubule formation in zebrafish, based on live imaging, proposing a dynamic endocytic capture model.

Bibliographic Details
Main Authors: Thomas E. Hall, Nick Martel, Nicholas Ariotti, Zherui Xiong, Harriet P. Lo, Charles Ferguson, James Rae, Ye-Wheen Lim, Robert G. Parton
Format: Article
Language:English
Published: Nature Publishing Group 2020-07-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-020-17486-w