Organoid Models of Glioblastoma and Their Role in Drug Discovery

Glioblastoma (GBM) is a devastating adult brain cancer with high rates of recurrence and treatment resistance. Cellular heterogeneity and extensive invasion of surrounding brain tissues are characteristic features of GBM that contribute to its intractability. Current GBM model systems do not recapit...

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Bibliographic Details
Main Authors: Matthew J. Rybin, Michael E. Ivan, Nagi G. Ayad, Zane Zeier
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-02-01
Series:Frontiers in Cellular Neuroscience
Subjects:
Online Access:https://www.frontiersin.org/articles/10.3389/fncel.2021.605255/full