Targeting Lymph Node Niches Enhances Type 1 Immune Responses to Immunization

Summary: Generating robust CD4+ T-helper cell type 1 (Th1) responses is essential for protective vaccine-induced type 1 immunity. Here, we examine whether immunization formulation associated with enhanced vaccine efficacy promotes antigen targeting and cell recruitment into lymph node (LN) niches as...

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Bibliographic Details
Main Authors: Jeffrey Lian, Aleksandra J. Ozga, Caroline L. Sokol, Andrew D. Luster
Format: Article
Language:English
Published: Elsevier 2020-05-01
Series:Cell Reports
Subjects:
Online Access:http://www.sciencedirect.com/science/article/pii/S221112472030632X