Nardosinone Suppresses RANKL-Induced Osteoclastogenesis and Attenuates Lipopolysaccharide-Induced Alveolar Bone Resorption

Nardosinone Suppresses RANKL-Induced Osteoclastogenesis and Attenuates Lipopolysaccharide-Induced Alveolar Bone Resorption

Periodontitis is a chronic inflammatory disease that damages the integrity of the tooth-supporting tissues, known as the periodontium, and comprising the gingiva, periodontal ligament and alveolar bone. In this study, the effects of nardosinone (Nd) on bone were tested in a model of lipopolysacchari...

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Bibliographic Details
Main Authors: Chenguang Niu, Fei Xiao, Keyong Yuan, XuChen Hu, Wenzhen Lin, Rui Ma, Xiaoling Zhang, Zhengwei Huang
Format: Article
Language:English
Published: Frontiers Media S.A. 2017-09-01
Series:Frontiers in Pharmacology
Subjects:
nardosinone
RANKL
osteoclastogenesis
alveolar bone resorption
MAPKs
Online Access:http://journal.frontiersin.org/article/10.3389/fphar.2017.00626/full

Internet

http://journal.frontiersin.org/article/10.3389/fphar.2017.00626/full

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