JC polyomavirus infection is strongly controlled by human leucocyte antigen class II variants.

JC polyomavirus infection is strongly controlled by human leucocyte antigen class II variants.

JC polyomavirus (JCV) carriers with a compromised immune system, such as in HIV, or subjects on immune-modulating therapies, such as anti VLA-4 therapy may develop progressive multifocal leukoencephalopathy (PML) which is a lytic infection of oligodendrocytes in the brain. Serum antibodies to JCV ma...

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Bibliographic Details
Main Authors: Emilie Sundqvist, Dorothea Buck, Clemens Warnke, Eva Albrecht, Christian Gieger, Mohsen Khademi, Izaura Lima Bomfim, Anna Fogdell-Hahn, Jenny Link, Lars Alfredsson, Helle Bach Søndergaard, Jan Hillert, International Multiple Sclerosis Genetics Consortium, Annette B Oturai, Bernhard Hemmer, Ingrid Kockum, Tomas Olsson
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-04-01
Series:PLoS Pathogens
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/24763718/?tool=EBI

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/24763718/?tool=EBI

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