Pre-clinical evaluation of a replication-competent recombinant adenovirus serotype 4 vaccine expressing influenza H5 hemagglutinin.

Pre-clinical evaluation of a replication-competent recombinant adenovirus serotype 4 vaccine expressing influenza H5 hemagglutinin.

Influenza virus remains a significant health and social concern in part because of newly emerging strains, such as avian H5N1 virus. We have developed a prototype H5N1 vaccine using a recombinant, replication-competent Adenovirus serotype 4 (Ad4) vector, derived from the U.S. military Ad4 vaccine st...

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Bibliographic Details
Main Authors: Jeff Alexander, Simone Ward, Jason Mendy, Darly J Manayani, Peggy Farness, Jenny B Avanzini, Ben Guenther, Fermin Garduno, Lily Jow, Victoria Snarsky, Glenn Ishioka, Xin Dong, Lo Vang, Mark J Newman, Tim Mayall
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3281928?pdf=render

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http://europepmc.org/articles/PMC3281928?pdf=render

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