Defective transcription elongation in a subset of cancers confers immunotherapy resistance

Defective transcription elongation in a subset of cancers confers immunotherapy resistance

Transcription elongation (TE) is a key point of inducible gene expression regulation. Here, the authors report widespread TE defects (TEdeff) in a high proportion of cancers that correlate with poor immunotherapy response, highlighting TE defects as potential routes for immune resistance.

Bibliographic Details
Main Authors: Vishnu Modur, Navneet Singh, Vakul Mohanty, Eunah Chung, Belal Muhammad, Kwangmin Choi, Xiaoting Chen, Kashish Chetal, Nancy Ratner, Nathan Salomonis, Matthew T. Weirauch, Susan Waltz, Gang Huang, Lisa Privette-Vinnedge, Joo-Seop Park, Edith M. Janssen, Kakajan Komurov
Format: Article
Language:English
Published: Nature Publishing Group 2018-10-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-018-06810-0

Internet

https://doi.org/10.1038/s41467-018-06810-0

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