Mechanisms underlying astrocytic connexin-43 autophagy degradation during cerebral ischemia injury and the effect on neuroinflammation and cell apoptosis

Mechanisms underlying astrocytic connexin-43 autophagy degradation during cerebral ischemia injury and the effect on neuroinflammation and cell apoptosis

Connexin-43 (Cx43) is the most abundant gap junction protein in the nervous system. It enables cell communication and has important physiological roles including ion transport and substrate exchange, all of which have been implicated in cerebral ischemia injury. Our previous in vitro and in vivo stu...

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Bibliographic Details
Main Authors: Xinyu Wang, Liangshu Feng, Meiying Xin, Yulei Hao, Xu Wang, Pei Shang, Mingming Zhao, Shuai Hou, Yunhai Zhang, Yun Xiao, Di Ma, Jiachun Feng
Format: Article
Language:English
Published: Elsevier 2020-07-01
Series:Biomedicine & Pharmacotherapy
Subjects:
Oxygen-glucose deprivation
Astrocytes
Cx43
OPTN
NDP52
PINK1
Online Access:http://www.sciencedirect.com/science/article/pii/S0753332220303176

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http://www.sciencedirect.com/science/article/pii/S0753332220303176

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