Parallel G-quadruplexes recruit the HSV-1 transcription factor ICP4 to promote viral transcription in herpes virus-infected human cells
Ilaria Frasson et al. find that the herpesvirus major transcription factor ICP4 regulates viral gene expression and replication through binding to parallel DNA G-quadruplexes (G4s). These results suggest that drugs targeting G4s at ICP4-regulated gene promoters could be an effective antiviral strate...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Publishing Group
2021-04-01
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| Series: | Communications Biology |
| Online Access: | https://doi.org/10.1038/s42003-021-02035-y |