Transport mechanisms and their pathology-induced regulation govern tyrosine kinase inhibitor delivery in rheumatoid arthritis.

Transport mechanisms and their pathology-induced regulation govern tyrosine kinase inhibitor delivery in rheumatoid arthritis.

BACKGROUND: Tyrosine kinase inhibitors (TKIs) are effective in treating malignant disorders and were lately suggested to have an impact on non-malignant diseases. However, in some inflammatory conditions like rheumatoid arthritis (RA) the in vivo effect seemed to be moderate. As most TKIs are taken...

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Bibliographic Details
Main Authors: Christian Schmidt-Lauber, Saliha Harrach, Thomas Pap, Meike Fischer, Marion Victor, Marianne Heitzmann, Uwe Hansen, Manfred Fobker, Stefan-Martin Brand, Aleksandra Sindic, Hermann Pavenstädt, Bayram Edemir, Eberhard Schlatter, Jessica Bertrand, Giuliano Ciarimboli
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3527388?pdf=render

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http://europepmc.org/articles/PMC3527388?pdf=render

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