The push-to-open mechanism of the tethered mechanosensitive ion channel NompC

The push-to-open mechanism of the tethered mechanosensitive ion channel NompC

NompC is a mechanosensitive ion channel responsible for the sensation of touch and balance in Drosophila melanogaster. Based on a resolved cryo-EM structure, we performed all-atom molecular dynamics simulations and electrophysiological experiments to study the atomistic details of NompC gating. Our...

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Bibliographic Details
Main Authors: Yang Wang, Yifeng Guo, Guanluan Li, Chunhong Liu, Lei Wang, Aihua Zhang, Zhiqiang Yan, Chen Song
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2021-06-01
Series:eLife
Subjects:
NompC
mechanosensitive ion channel
molecular dynamics
electrophysiology
gating
Online Access:https://elifesciences.org/articles/58388

Internet

https://elifesciences.org/articles/58388

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