Mechanisms of Coronavirus Cell Entry Mediated by the Viral Spike Protein

Coronaviruses are enveloped positive-stranded RNA viruses that replicate in the cytoplasm. To deliver their nucleocapsid into the host cell, they rely on the fusion of their envelope with the host cell membrane. The spike glycoprotein (S) mediates virus entry and is a primary determinant of cell tro...

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Bibliographic Details
Main Authors: Gary R. Whittaker, Beth N. Licitra, Sandrine Belouzard, Jean K. Millet
Format: Article
Language:English
Published: MDPI AG 2012-06-01
Series:Viruses
Subjects:
Online Access:http://www.mdpi.com/1999-4915/4/6/1011