Off-Target Effect of Endogenous siRNA Derived from RMRP in Human Cells

Off-Target Effect of Endogenous siRNA Derived from RMRP in Human Cells

Endogenous siRNAs (endo-siRNAs) are key regulators of RNA silencing in plants and worms; however, the biogenesis and function of endogenous siRNAs in mammals remain largely unknown. We previously demonstrated that human telomerase reverse transcriptase produces a self-targeting endogenous siRNA from...

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Bibliographic Details
Main Authors: Yoshiko Maida, Satoru Kyo, Timo Lassmann, Yoshihide Hayashizaki, Kenkichi Masutomi
Format: Article
Language:English
Published: MDPI AG 2013-04-01
Series:International Journal of Molecular Sciences
Subjects:
endogenous siRNA
hTERT
off-targeting
RNA-dependent RNA polymerase
Online Access:http://www.mdpi.com/1422-0067/14/5/9305

Internet

http://www.mdpi.com/1422-0067/14/5/9305

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