Yi-Qi-Jian-Pi Formula Suppresses RIPK1/RIPK3-Complex-Dependent Necroptosis of Hepatocytes Through ROS Signaling and Attenuates Liver Injury in Vivo and in Vitro

Yi-Qi-Jian-Pi Formula Suppresses RIPK1/RIPK3-Complex-Dependent Necroptosis of Hepatocytes Through ROS Signaling and Attenuates Liver Injury in Vivo and in Vitro

Acute-on-chronic liver failure (ACLF) is described as a characteristic of acute jaundice and coagulation dysfunction. Effective treatments for ACLF are unavailable and hence are urgently required. We aimed to define the effect of Yi-Qi-Jian-Pi Formula (YQJPF) on liver injury and further examine the...

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Bibliographic Details
Main Authors: Feixia Wang, Li Tang, Baoyu Liang, Chun Jin, Liyuan Gao, Yujia Li, Zhanghao Li, Jiangjuan Shao, Zili Zhang, Shanzhong Tan, Feng Zhang, Shizhong Zheng
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-04-01
Series:Frontiers in Pharmacology
Subjects:
acute-on-chronic liver failure
reactive oxygen species
inflammation
hepatocytes necroptosis
Yi-Qi-Jian-Pi formula
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2021.658811/full

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https://www.frontiersin.org/articles/10.3389/fphar.2021.658811/full

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